Promega and BASF have jointly developed an alternative method to animal studies that can reliably detect the allergenic potential of substances. Using a newly developed cell line, the reaction of skin cells to allergenic substances can now be demonstrated in the test tube. Allergic skin rea ... more
Promega and Leica Microsystems Sign Agreement to Develop Fluorescent Ligands Enabling Live Cell Imaging at the Sub 100 nm Range
15-08-2008: Promega Corp. announced that it has signed an agreement with Leica Microsystems to enable fluorescent imaging of proteins in live cells. Under the terms of the agreement, Promega will develop fluorescent ligands for its HaloTag fusion proteins, that will be used to label proteins within live cells so that they can be visualized with Leica's TCS STED (stimulated emission depletion) superresolution microscope. Developed in the laboratory of Dr. Stefan Hell of the Max-Planck Institute in Germany, STED microscopy enables the investigation of structural details below the 100nm range.
Commonly used fluorescent proteins such as GFP are not optimal for use with high-powered STED technology as they are prone to photobleaching and lack appropriate spectral properties. In addition, alternative methods of labeling proteins with fluorescent antibodies are only applicable for fixed cells. Therefore, the agreement between Promega and Leica Microsystems will enable imaging of proteins within live cells at sub 100nm range.
Promega has been working with Leica Microsystems since 2006 to develop novel ways to label proteins within cells using its proprietary HaloTag® technology.
Promega Corp. announced that it has signed an agreement with Leica Microsystems to enable fluorescent imaging of proteins in live cells. Under the terms of the agreement, Promega will develop fluorescent ligands for its HaloTag fusion proteins, that will be used to label proteins within liv ... more
Leica Biosystems announced that it has acquired Kreatech Diagnostics, a privately-held provider of DNA fluorescent in-situ hybridization (FISH) probes and target labeling reagents for microarrays. “We are very pleased with the acquisition of Kreatech, its extensive portfolio and development ... more
Leica Microsystems and Leica Biosystems have cemented ties with their Brazilian Leica distributor: All shares of Aotec Instrumentos Cientificos Ltda of São Paulo, Brazil, have been acquired. Aotec is a provider of microscopy and histopathology solutions and has been a Leica distributor for ... more
Fifty years ago the development of modern image analysis began. These early systems used to fill a whole room with electronics, very different from today’s elegant, distinctive desktop set-up. In 1962, the first automated system for the analysis of microscope images was developed by the Cam ... more
Up to 80 percent of our experience of our visual environment takes place via our visual perception. Without spatial vision, we would hardly be able to stay oriented. In recent decades, the neurosciences have gained many insights into the complex processes by which our brain's visual cortex ... more
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