Mechanism involved in novel drug design with potential to treat tuberculosis
A team of researchers from Instituto de Medicina Molecular (iMM) Lisboa successfully used a pioneer method to chemically modify a protein's components with potential medical applications and an impact in the fight against tuberculosis.
To design novel drugs it is essential to understand the molecular mechanisms that make up proteins of pathogenic bacteria. The team, led by Gonçalo Bernardes, used an innovative methodology that allows protein alteration in their native state along with organic chemistry, biological computation, biophysics and biochemistry techniques to modify proteins involved in infectious diseases.
Researchers were able to identify a novel molecular mechanism that works as a shield in a family of proteins that are present in pathogenic bacteria, named phosphates. In particular, the team observed the presence of a structural water molecule in a specific area that protects the protein of being inactivated by oxidative processes.
These results may impact the fields of medical chemistry and molecular medicine because they reveal a novel defence mechanism used by these pathogenic proteins which may prove essential in the way we think about novel drug design, particularly to increase specificity, potency and efficacy of future clinical tests.
- drug design
- pathogenic bacteria
- molecular medicine
- computational biology
- 1A sensor for the most important human cancer gene
- 2Scientists capture colliding organic nanoparticles on video for first time
- 3Eurofins expands its presence in India
- 4Symcel secures €3.6 million Horizon 2020 Phase II grant
- 5Manganese-based MRI contrast agent may be safer alternative to gadolinium-based agents
- 6Hummingbird Diagnostics and Saarland University Collaborate in Early Disease Detection Based on Molecular Markers
- 7New imaging technique peers inside living cells
- 8Computer program finds new uses for old drugs
- 9Clever use of mirrors boosts performance of light-sheet microscope
- 10Water world
- Mechanism involved in novel drug design with potential to treat tuberculosis
- Wavelength dispersive X-ray fluorescence spectrometry for the assessment of lead concentration in animal bone powder
- EMSA, Cefic and Cedre sign agreement for co-operation in the field of marine pollution involving chemicals