Scientists in Canada and the United States have developed a chip sensor for monitoring how drug candidates alter amyloid-β peptide aggregation that they hope could be used to find new treatments for Alzheimer’s disease. Research into Alzheimer’s disease has shown that the self-aggregation o ... more
Visualising DNA sequences
A new, fast way to analyse DNA could be used to sequence the genomes of viruses and in the future help tackle genetic disorders such as schizophrenia and congenital heart defects.
Robert Neely and colleagues have used a DNA methyltransferase enzyme to label the 5’-GCGC-3’ DNA sequences with a fluorescent marker. Immobilising and stretching the DNA on a surface then produces a unique and reproducible pattern when combined with the markers. The result is a ‘fluorocode’ - a simple description of the DNA sequence, which can be read and analyzed like a barcode. DNA barcodes using fluorescent tagging can be read quickly as labelled samples pass a detector, but Neely’s fluorocode gives significantly enhanced resolution and uses a much smaller number of DNA molecules.
Current DNA sequencing methods are able to sequence short regions of the genome. Regions that are either duplicated or deleted relative to a reference genome are an important cause of structural variation in the human genome with links to a variety of genetic disorders. But using current sequencing methods, studying these repeats is time consuming and labour intensive.
Original publication: Robert K. Neely, Peter Dedecker, Jun-ichi Hotta, Giedre, Urbanaviciute Saulius Klimašauskas and Johan Hofkens, Chemical Science., 2010.
- genetic disorders
- human genome
- fluorescence markers
- DNA sequencing
Scientists in the UK have developed a new class of MRI (magnetic resonance imaging) agents that promise to deliver clearer images more quickly. Chemical shifts from proton NMR normally fall between 0-12ppm, but water and fat resonate at 4.7 and 1.3ppm respectively, causing noise that can ov ... more
Scientists in China have developed a simple microchip that enables quick and inexpensive high-throughput screening of potential drug candidates in 3D cell cultures. Scientists often use cell-based high-throughput screening in the first stage of drug design as a technique to quickly identify ... more
This meeting aims to set the agenda for the surface-enhanced Raman scattering (SERS) field for the next 10 years, by bringing the community together to welcome in new emerging priority areas and embracing the diversity of approaches and disciplines which are contributing to the growth and u ... more
The Schools' Analyst Competition is a national competition run by the RSC's Analytical Division for first year sixth form students studying AS level Chemistry or equivalent (i.e. Year 12). The Analytical Division’s Regions hold heats, in early spring each year, to select a team or teams, to ... more
Droplet-based microfluidics has emerged as one of the most active research fields in microfluidics. As the world’s leading chemistry community, the Royal Society of Chemistry is pleased to collaborate with Zhejiang University to co-organise this Lab on a Chip International Symposium: Drople ... more
Specific regions of the brain are specialized in recognizing bodies of animals and human beings. By measuring the electrical activity per cell, scientists from KU Leuven, Belgium, and the University of Glasgow have shown that the individual brain cells in these areas do different things. Th ... more
Colorectal cancer is the third most common form of cancer globally and the second most common cause of cancer deaths. The chance of a cure is high if the cancer is detected early enough, but early detection is not a given. Researchers from VIB and KU Leuven - together with various European ... more
Disappointing results in clinical Alzheimer’s studies discourage doctors and scientists from continuing their research into ɣ-secretases and a possible treatment against Alzheimer’s disease. In Cell, the Alzheimer’s expert Bart De Strooper (VIB-KU Leuven) argues that these studies are not p ... more
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