Light-sheet microscopy is one of the most powerful method for imaging the development and function of whole living organisms. However, achieving high-resolution images with these microscopes requires manual adjustments during imaging. Researchers of the Max Planck Institute of Molecular Cel ... more
Max Planck Innovation grants rights for developing new nanoscopic method to Leica Microsystems
Max Planck Innovation, the technology transfer organization of the Max Planck Society, grants Leica Microsystems, Wetzlar, an exclusive license for implementing the latest generation of optical microscopes with a resolution far below the diffraction limit (nanoscopes). This innovative optical nanoscopy, named GSDIM (ground state depletion microscopy followed by individual molecule return), achieves image resolutions in the nanometer range - even in conventional wide field microscopes. GSDIM was developed by Professor Stefan Hell, director at the Max Planck Institute for Biophysical Chemistry in Göttingen, Germany, and his team.
True-to-detail imaging of the spatial arrangement of proteins and other biomolecules in cells and observing molecular processes - GSDIM makes this possible for researchers due to resolutions beyond the diffraction limit. The more insight science gains into these basic processes of life, the better it can find the causes of previously incurable diseases and develop suitable therapies.
One of the strengths of GSDIM is that it uses conventional fluorescence markers to image proteins or other biomolecules within the cells with sharpness down to a few nanometers. This includes fluorophores, which are routinely used in biomedical work, such as fluorescent proteins and rhodamines.
With GSDIM, the fluorescent molecules in the specimen are almost completely switched off using laser light. However, individual molecules spontaneously return to the fluorescent state, while their neighbours remain non-illuminating. In this way, the signals of individual molecules can be acquired sequentially using a highly sensitive camera system and their spatial position in the specimen can be measured and stored. An extremely high-resolution image can then be created from the position of many thousands of molecules. This enables cell components that are situated very close to one another and cannot be resolved using conventional wide field fluorescence microscopy to be spatially separated and sharply reproduced in an image.
- technology transfer
- Stefan Hell
- fluorescent proteins
- fluorescence microscopy
- fluorescence markers
labfolder GmbH and the Max Planck Society announced a licensing agreement to provide up to 11,000 Max Planck scientists with labfolder's laboratory data management digital platform. This is the first time that a tool for digital laboratory data management is being provided across an entire ... more
Twenty metres before the finish line Usain Bolt already opens his arms in triumph and ramps up his speed: even with his “handbrake” on, at 9.58 seconds, he runs the 100 metre stretch faster than anyone ever before in 2009 in Berlin. In the process, he reached a maximum speed of almost 45 ki ... more
An international team of scientists from Austria, Germany and the US has combined newly developed techniques in electron microscopy and protein assembly to elucidate how cells regulate one of the most important steps in cell division. When one cell divides into two - that is how all forms o ... more
Malignant cancer cells not only proliferate faster than most healthy cells in our bodies. They also generate more “junk”, such as faulty and damaged proteins. This makes cancer cells inherently more dependent on the most important cellular garbage disposal unit, the proteasome, which degrad ... more
To explore the most intricate structures of the brain in order to decipher how it functions – Stefan Hell's team of researchers at the Max Planck Institute for Biophysical Chemistry in Göttingen has made a significant step closer to this goal. Using the STED microscopy developed by Hell, th ... more
A new software called QED (Quantitative Electron Diffraction), which has been licensed by Max Planck Innovation, has now been released by HREM Research Inc., a Japan based company, which is developing products and services in the field of High-Resolution Electron Microscopy. QED allows tran ... more
Max Planck Innovation GmbH, the technology transfer organization of the Max Planck Society, has awarded an exclusive license for LifeAct to ibidi GmbH, a provider of cell analysis products, located in Martinsried near Munich. The novel peptide allows for actin, an important protein, to be m ... more
Max Planck Innovation GmbH, the technology transfer agency of the Max Planck Society, has signed a co-exclusive license agreement with Leica Microsystems and Carl Zeiss MicroImaging GmbH for the RESOLFT (reversible saturable optical fluorescent transitions) technology, a method providing mo ... more
Markus Lusser is the new President and Director of Leica Microsystems, headquartered in Wetzlar, Germany. This appointment became effective July 1, 2015. He succeeds Andries Peter Jan van den Broek who has left the company. Before joining Leica Microsystems, Markus Lusser was Vice President ... more
The Scientist magazine has chosen the Leica TCS SP8 STED 3X as one of the Top 10 Innovations 2014 that will change the way life scientists work. An independent jury of experts from science and industry selected the latest generation of Leica Microsystems’ super-resolution microscopes. This ... more
On Monday, October 20, 2014, Yale University West Campus will open the doors to a new microscopy Center of Excellence made possible through a partnership with Leica Microsystems. Housed in a newly created core facility, the Leica Center of Excellence at Yale West Campus will provide scienti ... more
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