Nanomaterials play an essential role in many areas of daily life. There is thus a large interest to gain detailed knowledge about their optical and electronic properties. Conventional microscopes get beyond their limits when particle size falls to the range of a few ten nanometers where a s ... more
Max Planck Innovation grants rights for developing new nanoscopic method to Leica Microsystems
Max Planck Innovation, the technology transfer organization of the Max Planck Society, grants Leica Microsystems, Wetzlar, an exclusive license for implementing the latest generation of optical microscopes with a resolution far below the diffraction limit (nanoscopes). This innovative optical nanoscopy, named GSDIM (ground state depletion microscopy followed by individual molecule return), achieves image resolutions in the nanometer range - even in conventional wide field microscopes. GSDIM was developed by Professor Stefan Hell, director at the Max Planck Institute for Biophysical Chemistry in Göttingen, Germany, and his team.
True-to-detail imaging of the spatial arrangement of proteins and other biomolecules in cells and observing molecular processes - GSDIM makes this possible for researchers due to resolutions beyond the diffraction limit. The more insight science gains into these basic processes of life, the better it can find the causes of previously incurable diseases and develop suitable therapies.
One of the strengths of GSDIM is that it uses conventional fluorescence markers to image proteins or other biomolecules within the cells with sharpness down to a few nanometers. This includes fluorophores, which are routinely used in biomedical work, such as fluorescent proteins and rhodamines.
With GSDIM, the fluorescent molecules in the specimen are almost completely switched off using laser light. However, individual molecules spontaneously return to the fluorescent state, while their neighbours remain non-illuminating. In this way, the signals of individual molecules can be acquired sequentially using a highly sensitive camera system and their spatial position in the specimen can be measured and stored. An extremely high-resolution image can then be created from the position of many thousands of molecules. This enables cell components that are situated very close to one another and cannot be resolved using conventional wide field fluorescence microscopy to be spatially separated and sharply reproduced in an image.
- technology transfer
- Stefan Hell
- fluorescent proteins
- fluorescence microscopy
- fluorescence markers
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A team of researchers from the Max Planck Institute for Nuclear Physics in Heidelberg, the Physikalisch-Technische Bundesanstalt in Braunschweig and the University of Aarhus in Denmark demonstrated for the first time Coulomb crystallization of highly-charged ions (HCIs). Inside a cryogenic ... more
To explore the most intricate structures of the brain in order to decipher how it functions – Stefan Hell's team of researchers at the Max Planck Institute for Biophysical Chemistry in Göttingen has made a significant step closer to this goal. Using the STED microscopy developed by Hell, th ... more
Prof. Dr. Dr. h. c. Stefan Hell of the Max Planck Institute for Biophysical Chemistry in Göttingen is to receive the 2011 Körber European Science Prize endowed with 750,000 euros for his pioneering discoveries in the field of optics. Every year, the Körber Prize is awarded to an outstanding ... more
Far-field optical nanoscopy methods, especially STED (stimulated emission depletion), pose very strict and, at times, contradictory requirements on the utilized fluorescent markers. Photostable fluorescent dyes that absorb in the red optical region are indispensable as labels for various mi ... more
A new software called QED (Quantitative Electron Diffraction), which has been licensed by Max Planck Innovation, has now been released by HREM Research Inc., a Japan based company, which is developing products and services in the field of High-Resolution Electron Microscopy. QED allows tran ... more
Max Planck Innovation GmbH, the technology transfer organization of the Max Planck Society, has awarded an exclusive license for LifeAct to ibidi GmbH, a provider of cell analysis products, located in Martinsried near Munich. The novel peptide allows for actin, an important protein, to be m ... more
Max Planck Innovation, the technology transfer organization of the Max Planck Society, grants Leica Microsystems, Wetzlar, an exclusive license for implementing the latest generation of optical microscopes with a resolution far below the diffraction limit (nanoscopes). This innovative optic ... more
Markus Lusser is the new President and Director of Leica Microsystems, headquartered in Wetzlar, Germany. This appointment became effective July 1, 2015. He succeeds Andries Peter Jan van den Broek who has left the company. Before joining Leica Microsystems, Markus Lusser was Vice President ... more
The Scientist magazine has chosen the Leica TCS SP8 STED 3X as one of the Top 10 Innovations 2014 that will change the way life scientists work. An independent jury of experts from science and industry selected the latest generation of Leica Microsystems’ super-resolution microscopes. This ... more
On Monday, October 20, 2014, Yale University West Campus will open the doors to a new microscopy Center of Excellence made possible through a partnership with Leica Microsystems. Housed in a newly created core facility, the Leica Center of Excellence at Yale West Campus will provide scienti ... more
Up to 80 percent of our experience of our visual environment takes place via our visual perception. Without spatial vision, we would hardly be able to stay oriented. In recent decades, the neurosciences have gained many insights into the complex processes by which our brain's visual cortex ... more
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