Single enantiomer using copper catalyst


Chemists in Switzerland show that a racemic mixture can be transformed into one enantiomer, using a copper catalyst.

The concept of the dynamic kinetic asymmetric transformation in allylic substitutions represents an efficient methodology for transforming a racemic mixture into one product.

Alexandre Alexakis and Jean-Baptiste Langlois from the University of Geneva, report the first dynamic kinetic asymmetric transformation in copper catalysed allylic alkylations.

Significantly, this is the first example of using a copper catalyst for this transformation and it could lead to further insights into the mechanisms of other copper catalysed reactions.

With further research the enantioselectivities of these systems could be improved and their application towards useful chiral synthons could be demonstrated suggested Alexakis.

‘There are still many interesting challenges in copper catalysed asymmetric transformations, as in asymmetric synthesis in general,’ says Alexakis. Work is underway in his team to explore other copper catalysed reactions.

Original article: Jean-Baptiste Langlois and Alexandre Alexakis; "Dynamic kinetic asymmetric transformation in copper catalyzed allylic alkylation"; Chem. Commun. 2009

Facts, background information, dossiers
  • copper
  • Switzerland
  • Asymmetric Synthesis
More about Royal Society of Chemistry
  • News

    Therapeutic screening for Alzheimer’s disease

    Scientists in Canada and the United States have developed a chip sensor for monitoring how drug candidates alter amyloid-β peptide aggregation that they hope could be used to find new treatments for Alzheimer’s disease. Research into Alzheimer’s disease has shown that the self-aggregation o ... more

    Moving the MRI goalposts

    Scientists in the UK have developed a new class of MRI (magnetic resonance imaging) agents that promise to deliver clearer images more quickly. Chemical shifts from proton NMR normally fall between 0-12ppm, but water and fat resonate at 4.7 and 1.3ppm respectively, causing noise that can ov ... more

    High-throughput drug screening in 3D

    Scientists in China have developed a simple microchip that enables quick and inexpensive high-throughput screening of potential drug candidates in 3D cell cultures. Scientists often use cell-based high-throughput screening in the first stage of drug design as a technique to quickly identify ... more

More about Université de Genève
  • News

    A fresh look inside the protein nano-machines

    Proteins perform vital functions of life, they digest food and fight infections and cancer. They are in fact nano-machines, each one of them designed to perform a specific task. But how did they evolve to match those needs, how did the genes encode the structure and function of proteins? Re ... more

    Screening the most useful nanoparticles for medicine

    The use of nanoparticles -- small, virus-sized elements developed under laboratory conditions -- is increasingly widespread in the world of biomedicine. This rapidly-evolving technology offers hope for many medical applications, whether for diagnosis or therapies. In oncology, for example, ... more

    Sequencing the cow's genetic code

    Researchers from the Universities of Geneva and Lausanne, as well as the Swiss Institute of Bioinformatics have been part of a major international project to sequence the bovine (cow) genome, a female Hereford cow named L1 Dominette. Sequencing the bovine genome is now complete, paving the ... more

Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE