Scientists in Canada and the United States have developed a chip sensor for monitoring how drug candidates alter amyloid-β peptide aggregation that they hope could be used to find new treatments for Alzheimer’s disease. Research into Alzheimer’s disease has shown that the self-aggregation o ... more
Single enantiomer using copper catalyst
Chemists in Switzerland show that a racemic mixture can be transformed into one enantiomer, using a copper catalyst.
The concept of the dynamic kinetic asymmetric transformation in allylic substitutions represents an efficient methodology for transforming a racemic mixture into one product.
Alexandre Alexakis and Jean-Baptiste Langlois from the University of Geneva, report the first dynamic kinetic asymmetric transformation in copper catalysed allylic alkylations.
Significantly, this is the first example of using a copper catalyst for this transformation and it could lead to further insights into the mechanisms of other copper catalysed reactions.
With further research the enantioselectivities of these systems could be improved and their application towards useful chiral synthons could be demonstrated suggested Alexakis.
‘There are still many interesting challenges in copper catalysed asymmetric transformations, as in asymmetric synthesis in general,’ says Alexakis. Work is underway in his team to explore other copper catalysed reactions.
Original article: Jean-Baptiste Langlois and Alexandre Alexakis; "Dynamic kinetic asymmetric transformation in copper catalyzed allylic alkylation"; Chem. Commun. 2009
- Asymmetric Synthesis
Scientists in the UK have developed a new class of MRI (magnetic resonance imaging) agents that promise to deliver clearer images more quickly. Chemical shifts from proton NMR normally fall between 0-12ppm, but water and fat resonate at 4.7 and 1.3ppm respectively, causing noise that can ov ... more
Scientists in China have developed a simple microchip that enables quick and inexpensive high-throughput screening of potential drug candidates in 3D cell cultures. Scientists often use cell-based high-throughput screening in the first stage of drug design as a technique to quickly identify ... more
Conference30-08 – 01-09
This meeting aims to set the agenda for the surface-enhanced Raman scattering (SERS) field for the next 10 years, by bringing the community together to welcome in new emerging priority areas and embracing the diversity of approaches and disciplines which are contributing to the growth and u ... more
The use of nanoparticles -- small, virus-sized elements developed under laboratory conditions -- is increasingly widespread in the world of biomedicine. This rapidly-evolving technology offers hope for many medical applications, whether for diagnosis or therapies. In oncology, for example, ... more
Peter Kündig and colleagues from Geneva University, Switzerland and Stephen Marsden and co-workers at the University of Leeds, in the UK, have developed an asymmetric Pd/N-heterocyclic carbene (NHC) - catalysed intramolecular -arylation of amide enolates, containing heteroatom sustituents. ... more