Topic microplate readers

Products microplate readers

BioTek Instruments Introduces the SynergyTM H4 Hybrid Microplate Reader

BioTek Instruments continues to expand its SynergyTM Multi-Mode Microplate Reader family with the introduction of the patent-pending Synergy H4 with Hybrid TechnologyTM. Synergy H4 combines the sensitivity of filter-based optics with the more

News microplate readers

• Tecan Award 2011 winner announced

  Tecan announced the results of the Tecan Award 2011. The award has been won by Svenja Kristina Holle from the University Hospital of Muenster (UHM), Germany. Using an Infinite® 200 microplate reader, Svenja and the UHM team have developed an ex vivo method for investigating the dynamics of organic c more

• Invitrogen Corporation Announces Strategic Collaboration with Tecan

  Invitrogen Corporation and Tecan are entering into a collaboration agreement to validate the compatibility of Invitrogen's reagents with Tecan's microplate detection instruments. Invitrogen's drug discovery products will be validated on selected Tecan microplate readers and instruments, starting wi more

White papers microplate readers

• Homogeneous IgG AlphaLISA® assay performed on BMG LABTECH's PHERAstar Plus
  

  Immunoglobulins or antibodies are proteins that are involved in the immune response. That makes them interesting drug targets. This application note shows the detection of the immunoglobulin IgG using an AlphaLISA® assay performed on BMG LABTECH's PHERAstar Plus. The AlphaLISA® technology utilizes oxygen to start a cascade of chemical reactions resulting in a luminescence signal at 615 nm. Sensitivity and Z´values obtained in different plate formats are presented. more

• Predictor(TM) hERG Fluorescence Polarization Assay Kit performed on the PHERAstar/PHERAstar Plus
  

  The potential for cardiotoxic side-effects continues to challenge the development of small molecule based therapies. These intolerable side-effects are often precipitated by drug-induced long QT syndrome (LQT), which is often linked to blocking the human ether-a-go-go related gene (hERG) potassium channel. Although patch-clamp electrophysiology remains the gold standard for determining the interaction of compounds with the function of the hERG channel, radioligand displacement assays have proven to be a cost-effective initial alternative assay for hERG channel liability at early stages of compound development. more

• Detection of NADH and NADPH with the Omega's High Speed, Full UV/Vis Absorbance Spectrometer
  

  Nicotinamide Adenine Dinucleotide (NAD+), reduced nicotinamide adenine dinucleotide (NADH), nicotinamide adenine dinucleotide phosphate (NADP+) and reduced nicotinamide adenine dinucleotide phosphate (NADPH) have been known to play vital roles in energy metabolism, antioxidation, and reductive biosynthesis. In recent years, these co-factors have been shown to be involved in other physiological functions as well, including aging, oxidative stress, intracellular calcium homeostasis, ROS production, cell death and gene expression. more

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