Topic fluorescence

Products fluorescence

Thermal Field-Flow Fractionation: Ultra-Broad Polymer Separation

The new Postnova TF2000-MALS series is a truly unique and innovative technology for polymer/particle separation and characterization. The analysis can be achieved over a huge molar mass and size range and under extremely gentle conditions without any shear forces and sample degradation more

Catalogues fluorescence

The new Shimadzu product catalogue

Eleven product folders, six product segments, one kit - the new Shimadzu product catalogue features the complete package in analytical instrumentation more

News fluorescence

• New ways to diagnose skin cancer?

  A biopsy is a painful and scarring but often unavoidable procedure, to decide whether a suspicious looking region on the skin is cancer or a harmless spot. Now, scientists attained promising results of autofluorescence and reflectance measurements of tissue as a noninvasive approach for basal cell c more

• Good timing: NIST/CU collaboration adds timing capability to living cell sensors
  

  Individual cells modified to act as sensors using fluorescence are already useful tools in biochemistry, but now they can add good timing to their resumé, thanks in part to expertise from the National Institute of Standards and Technology (NIST).With the added capability to track the timing of dynam more

• The 2011 Körber Prize goes to Stefan Hell

  Prof. Dr. Dr. h. c. Stefan Hell of the Max Planck Institute for Biophysical Chemistry in Göttingen is to receive the 2011 Körber European Science Prize endowed with 750,000 euros for his pioneering discoveries in the field of optics. Every year, the Körber Prize is awarded to an outstanding scientis more

White papers fluorescence

• Homogeneous IgG AlphaLISA® assay performed on BMG LABTECH's PHERAstar Plus
  

  Immunoglobulins or antibodies are proteins that are involved in the immune response. That makes them interesting drug targets. This application note shows the detection of the immunoglobulin IgG using an AlphaLISA® assay performed on BMG LABTECH's PHERAstar Plus. The AlphaLISA® technology utilizes oxygen to start a cascade of chemical reactions resulting in a luminescence signal at 615 nm. Sensitivity and Z´values obtained in different plate formats are presented. more

• Predictor(TM) hERG Fluorescence Polarization Assay Kit performed on the PHERAstar/PHERAstar Plus
  

  The potential for cardiotoxic side-effects continues to challenge the development of small molecule based therapies. These intolerable side-effects are often precipitated by drug-induced long QT syndrome (LQT), which is often linked to blocking the human ether-a-go-go related gene (hERG) potassium channel. Although patch-clamp electrophysiology remains the gold standard for determining the interaction of compounds with the function of the hERG channel, radioligand displacement assays have proven to be a cost-effective initial alternative assay for hERG channel liability at early stages of compound development. more

• Molecular Probes® NanoOrange® Assay Performed on BMG LABTECH FLUOstar OPTIMA Microplate Reader
  

  The field of proteomics has expanded dramatically in recent years with research on a whole host of organisms. Techniques such as two dimensional difference gel electrophoresis (2D DIGE) require the accurate quantitation of protein, as up to three labelled samples can be loaded on a single gel for comparison. Assay methods for determining protein quantitation include absorbance at 280 nm(1), the Bradford assay(2), Lowry assay(3), BCA method(4) and more sensitive assays such as Fluoroprofile® (Sigma-Aldrich) and NanoOrange® (Molecular Probes®)5(). more

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