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• New microscope reveals ultrastructure of cells
  

  Researchers at Helmholtz-Zentrum Berlin (HZB) have developed a new X-ray nanotomography microscope. Using their new system, they can reveal the structures on the smallest components of mammalian cells in three dimensions. For the first time, there is no need to chemically fix, stain or cut cells in more

• Novel process for DNA labeling

  For the first time, baseclick GmbH, a start-up company spun off from BASF SE and Ludwig-Maximilians-Universität Munich, is making its newly developed process for labeling nucleic acids (DNA and RNA) available to customers. The company recently signed licensing agreements for this technology with thr more

• Move to the red!

  Stable dyes with sharp absorption and fluorescence emission bands in the red or NIR region of the spectrum, combined with high molar absorption coefficients and high fluorescence quantum yields, may find extensive use in many different fields, such as optical engineering, analytical chemistry, biolo more

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• New Application for the LightCycler® 480 System: Gene Scanning by High-Resolution Melting
  

  High-resolution melting (HRM) is a novel, homogeneous, post-PCR method, enabling genomic researchers to analyze genetic variations (SNPs, mutations, methylations) in PCR amplicons. The most important high-resolution melting application is gene scanning - the search for the presence of unknown variations in PCR amplicons prior to or as an alternative to sequencing. more

• Quantification of Zea mays mRNAs by Real-Time PCR Using the Universal ProbeLibrary
  

  The Universal ProbeLibrary (UPL) is a detection system for real-time PCR based on locked nucleic acid (LNA) probes. We tested the efficiency of the UPL for the quantification of maize transcripts on two detection platforms. The results indicate that the UPL is an attractive alternative to assays based on intercalating dyes or conventional probes. more

• Novel Methods for High-Performance Melting Curve Analysis Using the LightCycler® 480 System
  

  The LightCycler® Real-time PCR Systems provide fast, accurate, and versatile platforms for genetic variation research. They feature the temperature homogeneity and the optical characteristics re-quired for high-performance melting curve analysis. The plate-based LightCycler® 480 System now facilitates advanced applications in the emerging field of amplicon scanning for new mutations at high resolution. more

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