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Products Determination

Two new microwave reaction systems providing the best solutions for your sample preparation

Based on its longstanding experience, Anton Paar launches two new microwave reaction systems for sample preparation: Multiwave PRO and Multiwave ECO more

Separate proteins faster

Proteins can be analyzed or purified up to 3x faster with pressure-resistant glass columns of KNAUER Bioline and specially reinforced agarose media more

Real Time TOC Analytics

The high measuring performance of the Thornton 5000TOC sensor provides very short response times in combination with easy handling and low maintenance more

News Determination

• U of T Researchers Develop “Hi-Def” Copy Number Variation Decoder

  University of Toronto researchers have developed a new “high definition” computer program to analyze human DNA and more accurately detect genetic variants that affect individual traits like disease susceptibility and varying drug responses. A multi-disciplinary team combining computer science and b more

• Dionex Demonstrates Simplified Determination of 2-Ethylhexanoic Acid in Clavulanate

  Dionex announced a simplified method for the detection and quantification of 2-ethylhexanoic acid, a potential impurity in potassium clavulanate active pharmaceutical ingredient (API) incorporated during sample purification. Application Note 262: Determination of 2-Ethylhexanoic Acid Impurity in Cla more

• Move to the red!

  Stable dyes with sharp absorption and fluorescence emission bands in the red or NIR region of the spectrum, combined with high molar absorption coefficients and high fluorescence quantum yields, may find extensive use in many different fields, such as optical engineering, analytical chemistry, biolo more

White papers Determination

• Field-Flow Fractionation - The Universal Separation Principle for Particle and Macromolecule Characterization
  

  High molecular weight polymers, bio molecules or particles in a range of a few nanometers up to several microns are more and more important in science and technology. Many applications are based on the specific properties of these materials. For this reason, an exact knowledge of the molar mass or particle sizes distribution is essential for later application as well as for optimization of the production processes or quality control. In addition the knowledge about the chain structure of macromolecules or biopolymers as well as about the shape of particles is often necessary. For this reason those samples, which often can be very complex systems, have to be separated according to parameters such as e.g. hydrodynamic volume or molecular weight. After the separation process the resulting narrow dispersed fractions are detected with different techniques. more

• Automated Dynamic Light Scattering
  

  DLS analysis is a widely applied, non-invasive method for measuring the effective size of molecules in solution. This technique yields valuable information for the characterization of molecules and particles. It facilitates formerly laborious and time consuming measurements, e.g. screening for aggregates or determining optimal crystallization conditions for proteins. The Wyatt Plate Reader is the instrument of choice for any application where molecular size, stability and aggregation are of interest. It reads industry standard microplates with up to 1536 samples automatically and temperature-controlled, if desired. The applications of the technique are wide ranging and include many of the fastest growing areas of research - proteins, biomaterials, liposomes and micelles as well as the established uses for particle sizing and aggregation detection. Conscious of the numerous characterization challenges in the area of drug delivery systems and therapeutic antibodies more

• Homogeneous IgG AlphaLISA® assay performed on BMG LABTECH's PHERAstar Plus
  

  Immunoglobulins or antibodies are proteins that are involved in the immune response. That makes them interesting drug targets. This application note shows the detection of the immunoglobulin IgG using an AlphaLISA® assay performed on BMG LABTECH's PHERAstar Plus. The AlphaLISA® technology utilizes oxygen to start a cascade of chemical reactions resulting in a luminescence signal at 615 nm. Sensitivity and Z´values obtained in different plate formats are presented. more

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