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News breast cancer

• Breast cancer risk gene discovery fast tracked by new technology

  An international team of researchers led by the University of Melbourne has used new technology to fast track the discovery of a breast cancer risk gene and could assist in the discovery of other cancer genes.Professor Melissa Southey of the Genetic Epidemiology Laboratory, Department of Pathology a more

• Exonhit Announces Successful Completion of the Second Phase of EHT Dx14 Clinical Validation

  Following the first data in benign and malignant fine-needle aspiration (FNA) samples, Exonhit announced successful completion of the second phase of the validation study of EHT Dx14, a new transcriptomic signature allowing to differentiate, at molecular level, benign breast tumors from malignant on more

• Study of biomarker development in mice provides a roadmap for a similar approach in humans

  Researchers at Fred Hutchinson Cancer Research Center have demonstrated in mice that the performance of a novel biomarker-development pipeline using targeted mass spectrometry is robust enough to support the use of an analogous approach in humans. The findings, by principal investigator Amanda Paulo more

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• Analysis of the DNA Methylation Patterns at the BRCA1 CpG Island
  

  Germ-line alterations of the BRCA1 gene confer a lifetime risk of 40% for ovarian cancers and of 40%-80% for ­breast cancers. It is likely that BRCA1 acts as a tumor suppressor gene. BRCA1 involvement in breast cancers does not seem to be restricted to familial cancers. Despite the absence of somatic mutations in the breast tissues, a down regulation of BRCA1 expression is associated with malignancy in human sporadic breast cancers. more

• Quantification of BRCA1 Expression Level Using Standard RT-PCR Reagents - a Sensitive Method for the Detection of Low Amounts of Transcripts
  

  Mutations in the breast cancer susceptibility gene, BRCA1, occur in the majority of families with multiple members affected with breast or ovarian cancer. Women who inherit a BRCA1 mutation have 40%-80% risk of developing breast cancer or ovarian cancer. However, up to 90% of breast cancers are sporadic, and mutations in BRCA1 seem to be a rare event in sporadic breast tumors. more

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