Reaction Progress Kinetic Analysis: A Powerful Methodology for Streamlining the Study of Complex Organic Reactions

Reaction Progress Kinetic Analysis (RPKA) streamlines kinetic studies by exploiting the extensive data available from accurate in situ monitoring of global reaction progress under “synthetically relevant” conditions, where the concentrations of two or more reactants are changing simultaneously – in fact, in the same manner that they are expected to change during practical synthesis. At its most basic level, the RPKA methodology consists of two sets of experiments, called “same excess” and “different excess” experiments. The first Webinar in this series focused on the “different excess” protocol, showing how it provides the concentration dependence of different reactants. The principal advantage of RPKA in this case is that this information is obtained from far fewer experiments than required for traditional kinetic analysis, This Webinar focuses on the “same excess” protocol, which addresses the question of process robustness. Here the RPKA methodology is at its most innovative, because here it extracts information about a working catalytic cycle that is difficult to obtain by any other means: “same excess” experiments help to differentiate a catalyst cycle that is operating at steady-state from one which is subject to temporal effects unrelated to the intrinsic reaction kinetics, such as catalyst activation or deactivation.

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