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New Silicone Technologies for Skin Care
In today's competitive skin care market, consumers look for a range of benefits, superior aesthetics and cost effectiveness. In response, formulators strive to create products that are multifunctional, easy to use and effective in small quantities. At the same time, the most successful products deliver benefits that stand out from those of the competition. Creams, lotions and color cosmetics must be easy to spread and comfortable to wear, without feeling tacky or greasy. Silicones have been popular ingredients in skin care products for more than fifty years. These versatile materials are known for their emolliency, wetting and spreading characteristics and ability to provide unique aesthetics. As technology continues to evolve, silicones increasingly offer multifunctional, high performance properties. This article reviews some of the newest silicone technologies available for the formulation of innovative skin care products...
Automated Dynamic Light Scattering
DLS analysis is a widely applied, non-invasive method for measuring the effective size of molecules in solution. This technique yields valuable information for the characterization of molecules and particles. It facilitates formerly laborious and time consuming measurements, e.g. screening for aggregates or determining optimal crystallization conditions for proteins. The Wyatt Plate Reader is the instrument of choice for any application where molecular size, stability and aggregation are of interest. It reads industry standard microplates with up to 1536 samples automatically and temperature-controlled, if desired. The applications of the technique are wide ranging and include many of the fastest growing areas of research - proteins, biomaterials, liposomes and micelles as well as the established uses for particle sizing and aggregation detection. Conscious of the numerous characterization challenges in the area of drug delivery systems and therapeutic antibodies...
Asymmetric Flow Field Flow Fractionation (AF4) - A Powerful Method for Polymer Characterization
The AF4-MALS combined technique can serve as a routine method for polymer analysis and characterization. AF4 provides separation efficiency entirely comparable with traditionally used and so far dominating SEC. In addition, it yields superior separation of branched polymers, polymers containing ultra high molar mass fractions up to at least 108 g/mol, and nanoparticles. This contribution outlines the theoretical background of the method and shows several examples of its use, e.g. separation of high molecular weight polymers and particles. While SEC will certainly continue to be the most frequently employed method of polymer analysis, for many samples the description of molecular structure is more detailed if both SEC and AF4 are used. The possibility to run both SEC and AF4 on the same experimental set-up makes the AF4 method a powerful and versatile tool for the characterization of a variety of synthetic and natural polymers and related materials....
Burn injuries under freezing (labor protection) conditions?
Optimal protection when handling cryogenic liquefied gases
"A little splash of liquid nitrogen hasn't hurt anybody" - this happens to be a widespread opinion in many laboratories. The real dangers connected to cryogenic gases many people had to learn firsthand, unexpected and painful. Skin irritation, cell and tissue damage or severe burn injuries may occur, depending on the type of contact and exposure time. There are less possibilities of medical treatment than for injuries caused by influence of heat...
Polyether-Modified Silicones for Cosmetic Applications
Polyether-modified silicones have a long history of use in the personal care industry as emulsifiers and dispersants, as well as stabilizers for water-in-oil systems. However, because of their external phase type, water-in-oil systems tend to display poor aesthetics, such as greasiness, tackiness and slow absorption. A new polyether-modified silicone, PEG/PPG-19/19 dimethicone (and) C13-16 isoparaffin (and) C10-13 isoparaffin, was evaluated for its potential to aid in the production of stable water-in-silicone and water-in-oil formulations with unique textures and enhanced aesthetics. Various oil phases were studied, including silicone oils, organic oils, and a combination of both. Results of the evaluations demonstrate the versatility of the new material, and prototype formulations illustrate its broad utility...

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